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Intermediate
A 61-year-old receiving pembrolizumab develops new diarrhea 8 stools/day over baseline and abdominal pain. Infectious workup is pending, and CT suggests colitis. Which management is most appropriate?
Continue pembrolizumab and give loperamide only
Hold pembrolizumab and start systemic corticosteroids after evaluation
Start filgrastim because diarrhea indicates neutropenia
Give naloxone for immune toxicity
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