Biology Practice Test

140 questions available

Build your confidence for Biology. Practice the concepts, understand the answers, and strengthen your knowledge one question at a time.

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Certification exam
115 Exam questions
1 hour 30 minutes Time Limit
Your practice
140 Practice questions
2 hours 20 minutes Practice Time
Try 5 free questions
No account needed. A free account includes 20 questions for this exam.
The bar to clear 50 Published passing score for this certification.
Explore exam topics Official objectives from CLEP
CLEP140 practice questions
Blueprint verifiedChecked against CLEP official objectivesMetadata verified 2026-06-07How we verify

Exam overview and details

The Biology Certification Exam is a rigorous, industry-recognized assessment that validates a candidate's comprehensive understanding of core biological principles and their application in professional, research, and educational contexts. Achieving this certification demonstrates mastery across cellular and molecular biology, genetics, evolution, ecology, and organismal biology. It signifies not only a deep theoretical knowledge but also the analytical skills necessary to interpret data, solve complex biological problems, and apply scientific reasoning. Recognized by academic institutions, research organizations, and biotechnology firms, this credential serves as an objective benchmark of competency, distinguishing certified professionals in a competitive field. It is particularly valuable for educators, lab technicians, research assistants, and professionals in healthcare or environmental science seeking to formalize and verify their expertise, thereby enhancing their credibility and professional standing.

Sample Questions

Choose an answer and explore the explanation to see how practice works.

Organismal Biology

A fetus receives oxygen and nutrients from maternal blood without the two blood supplies normally mixing directly. Waste products move in the opposite direction across the same organ. Which structure performs this exchange?

Molecular and Cellular Biology

On a hot, dry day, a corn plant keeps photosynthesis relatively high by first fixing CO2 into a four-carbon compound in mesophyll cells and then releasing CO2 near Rubisco in bundle-sheath cells. What advantage does this pathway provide?

Population Biology

Acacia trees provide hollow thorns and nectar to ants. The ants attack herbivores and remove competing vines, increasing acacia survival. Which interaction is described?

Molecular and Cellular Biology

In an E. coli culture, tryptophan is abundant. The trp repressor binds corepressor and attaches to the operator, reducing transcription of enzymes needed for tryptophan synthesis. What is the logic of this regulation?

Molecular and Cellular Biology

In a photosynthetic bacterium, scientists find RNA molecules that can both store sequence information and catalyze bond formation. They use this observation to discuss early life before DNA genomes and protein enzymes. Which hypothesis does it support?

Exam insights and study advice

In the rapidly advancing fields of life sciences, biotechnology, and healthcare, a validated standard of knowledge is critical for career progression and professional credibility. This certification provides tangible proof of your biological expertise, directly impacting hiring decisions, promotion potential, and salary negotiations. It signals to employers, peers, and academic institutions a commitment to professional excellence and a foundational competency that is essential for roles in research, education, clinical support, and regulatory affairs. Industry recognition of this credential opens doors to advanced opportunities and establishes you as a qualified professional with a verified, standardized skill set that meets current industry and academic standards.

These are the backgrounds the certifying body suggests. Check the vendor's own page for anything it formally requires.

What this exam covers

Use the published domain weights to plan your study. Practice results do not predict your certification exam score.

01Organismal Biology

34%

Topics

  • Structure and function in plants with emphasis on angiosperms
  • Structure and function in animals with emphasis on vertebrates
  • Principles of heredity

Learning objectives

  • Structure and function in plants with emphasis on angiosperms: Root, stem, leaf, flower, seed, and fruit; Water and mineral absorption and transport; Food translocation and storage; Plant reproduction and development; Alternation of generations in ferns, conifers, and flowering plants; Gamete formation and fertilization; Growth and development: hormonal control; Tropisms and photoperiodicity
  • Structure and function in animals with emphasis on vertebrates: Major systems (e.g., digestive, gas exchange, skeletal, nervous, circulatory, excretory, and immune); Homeostatic mechanisms; Hormonal control in homeostasis and reproduction; Animal reproduction and development; Gamete formation and fertilization; Cleavage, gastrulation, germ layer formation, and differentiation of organ systems; Experimental analysis of vertebrate development; Extraembryonic membranes of vertebrates; Formation and function of the mammalian placenta; Blood circulation in the human embryo
  • Principles of heredity: Mendelian inheritance (dominance, segregation, independent assortment); Chromosomal basis of inheritance; Linkage, including sex-linked; Polygenic inheritance (height, skin color, etc.); Multiple alleles (human blood groups)

02Molecular and Cellular Biology

33%

Topics

  • Chemical composition of organisms
  • Simple chemical reactions and bonds
  • Properties of water
  • Chemical structure of carbohydrates, lipids, proteins, and nucleic acids
  • Origin of life
  • Cells
  • Enzymes
  • Energy transformations
  • Cell division
  • Chemical nature of the gene

Learning objectives

  • Chemical composition of organisms
  • Simple chemical reactions and bonds
  • Properties of water
  • Chemical structure of carbohydrates, lipids, proteins, and nucleic acids
  • Origin of life
  • Cells: Structure and function of cell organelles; Properties of cell membranes; Comparison of prokaryotic and eukaryotic cells
  • Enzymes: Enzyme-substrate complex; Roles of coenzymes; Inorganic cofactors; Inhibition and regulation
  • Energy transformations: Glycolysis, cellular respiration, aerobic and anaerobic pathways; Photosynthesis
  • Cell division: Structure of chromosomes; Mitosis, meiosis, and cytokinesis in plants and animals
  • Chemical nature of the gene: Watson-Crick model of nucleic acids; DNA replication; Mutations; Control of protein synthesis: transcription, translation, and post-transcriptional processing; Structural and regulatory genes; Transformation; Viruses

03Population Biology

33%

Topics

  • Principles of ecology
  • Principles of evolution
  • Classification of living organisms
  • Evolutionary history of humans
  • Principles of behavior
  • Human population growth
  • Human intervention in the natural world

Learning objectives

  • Principles of ecology: Energy flow and productivity in ecosystems; Biogeochemical cycles; Population growth and regulation (natality, mortality, competition, migration, density, r- and K-selection); Community structure, growth, and regulation (major biomes and succession); Habitat (biotic and abiotic factors); Concept of niche; Island biogeography
  • Principles of evolution: History of evolutionary concepts; Concepts of natural selection (differential reproduction, mutation, Hardy-Weinberg equilibrium, speciation, and punctuated equilibrium); Adaptive radiation; Major features of plant and animal evolution; Concepts of homology and analogy; Convergence, extinction, balanced polymorphism, and genetic drift
  • Classification of living organisms
  • Evolutionary history of humans
  • Principles of behavior: Stereotyped and learned social behavior; Societies (insects, birds, and primates); Social biology
  • Human population growth: Age composition, birth and fertility rates, and theory of demographic transition
  • Human intervention in the natural world: Management of resources, and environmental pollution; Biomedical progress (control of human reproduction, and genetic engineering)

Exam Details BIO | $93 USD | 1 hour 30 minutes

Exam Code BIO
Vendor CLEP
Exam Cost $93 USD
Passing Score 50
Time Limit 1 hour 30 minutes
Exam questions 115
Question Types Multiple choice (100%)
Retake Policy Each institution reserves the right to set its own credit-granting policy, which may differ from the American Council on Education (ACE). Contact your college to find out the score required for credit and the number of credit hours granted.
Exam Format Multiple-choice (computer-based)
Available In
English

Frequently Asked Questions

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