COMLEX-USA Level 2 CE Cognitive Evaluation Practice Test
Build your confidence for COMLEX-USA Level 2 CE Cognitive Evaluation. Practice the concepts, understand the answers, and strengthen your knowledge one question at a time.
Try a sample questionExam overview and details
COMLEX Level 2 cognitive examination covering clinical sciences with osteopathic medicine applications for osteopathic medical students. Administered by National Board of Osteopathic Medical Examiners as a linear computer-based (levels 1, 2-ce, 3 at prometric); osce (level 2-pe, suspended) format exam. Key domains include Clinical Presentation-Based Assessment, Diagnosis, Health Promotion and Disease Prevention and Osteopathic Principles in Clinical Setting. The exam consists of 400 questions over 540 minutes.
Sample Questions
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A 64-year-old man presents with fatigue and dyspnea on exertion. CBC: hemoglobin 9.2 g/dL, MCV 72 fL. Iron studies: serum iron 32 mcg/dL (low), TIBC 480 mcg/dL (high), ferritin 9 ng/mL (low). He has no known menstrual loss (he is male) and no obvious bleeding. According to current AGA and ACG guidance on iron-deficiency anemia, which is the MOST appropriate next diagnostic step?
A 42-year-old woman has ascending weakness, areflexia, and paresthesias 10 days after diarrheal illness. Vital capacity is declining but sensation is mostly intact. What is the most appropriate disease-directed treatment?
A 72-year-old woman from a long-term care facility presents with fever 39.4C, hypotension (BP 78/52 mmHg), tachycardia (118 bpm), tachypnea (RR 26), confusion, and lactate 4.2 mmol/L. She has a urinary catheter and a productive cough. Blood cultures are obtained. According to the 2021 Surviving Sepsis Campaign guidelines, which combination MUST be completed within the first hour ("hour-1 bundle")?
A 71-year-old man with atrial fibrillation on warfarin presents with acute onset of right-sided weakness and aphasia 90 minutes ago. Last-known-well time is documented. INR is 1.4. According to current AHA/ASA guidance, which initial imaging strategy is MOST appropriate to determine eligibility for IV thrombolysis?
A 68-year-old man with hypertension, hyperlipidemia, smoking, and atypical chest discomfort has a pre-test probability of obstructive coronary disease estimated at 50 percent. He undergoes exercise treadmill stress testing without imaging. The result is described as "non-diagnostic" because he was unable to achieve target heart rate (only 70 percent of age-predicted maximum). Per 2021 AHA/ACC chest pain guidance, what is the MOST appropriate next step?
Exam insights and study advice
This exam matters because it directly evaluates the core cognitive competencies required for safe and effective patient care in residency and beyond. It is not merely an academic hurdle; it is a standardized validation of your clinical judgment. Performance on the COMLEX-USA Level 2 CE is a key factor used by residency program directors during the Match process to assess your preparedness for the rigors of internship. Successfully passing signifies that you possess the essential medical knowledge and problem-solving skills to begin supervised practice, forming a foundational pillar of your professional credentialing.
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